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Weight loss and lean mass loss from burn induced catabolism can be more rapidly restored when the anabolic steroid oxandrolone is added to optimum nutrition compared to nutrition alone. This is attributed to the higher concentrations of oxandrolone in the diet (30 to 60 mg/kg) and the resulting weight loss caused by weight stability and the reduction in the activity of the anabolic androgen receptor and the reduction in the concentration of oxandrolone in the plasma at a constant dose of oxandrolone (30 mg/kg/d), as well as the lack of any of the catabolic reactions that occur when the oxandrolone is added to the diet. This provides an opportunity to make weight loss from oxandrolone more rapid if the diet is supplemented with an adequate amount of oxandrolone. TABLE 1 Oxandrolone: a substrate for fat oxidation? Oxandrolone: a substrate for fat oxidation? View Large TABLE 1 Oxandrolone: a substrate for fat oxidation? Oxandrolone: a substrate for fat oxidation? Oxandrolone as a substrate for the lipolytic process: it is a substrate for lipolysis. Lipolysis is the rate constant of the body's energy expenditure. Lipolysis is the energy required to oxidize glucose for glucose supply in the cells. Oxandrolone has been reported to increase the rate of lipogenesis without producing any catabolic effects, by promoting the conversion of fatty acids to acetylated fatty acids and to their hydroxylated and ketone bodies, in adipose tissue of non-obese obese humans (31, 32). However, in a double-blind study, oxandrolone did not enhance the lipogenic effect of sucrose (33). Moreover, oxandrolone does not affect lipolysis of fat in rats (34) or humans (35) despite its greater potency in vivo than sucrose (31), and animal studies do not provide useful information on the efficacy and mechanism of oxandrolone's weight loss effects (36). In a cross-sectional study in obese subjects, Oxandrolone significantly stimulated the release of adiponectin (11). This release of adiponectin was reduced by high doses of other anabolic steroids or by weight loss, suggesting that a high lipid content of the diet, in addition to the presence of high plasma levels of oxandrolone, reduces adiponectin secretion in humans (1). Vitality Oxandrolone (31) increases physical activity, and exercise enhances physical activity by releasing anabolic hormones and increasing the levels of circulating free Related Article: